Research
Contributing to heart and vascular research in our community
Curans Heart Centre takes part in industry-sponsored clinical trials and leads its own investigator-initiated research. Below are the studies currently running, opening soon or in planning at our clinic.
Industry-sponsored clinical trials (6)
Studies funded by pharmaceutical companies and conducted at our clinic.
| Disease area | Study | Sponsor | Phase | Status | Registry |
|---|---|---|---|---|---|
| Obesity |
Efficacy and safety of maridebart cafraglutide in adults without type 2 diabetes who have obesity or are overweight (MARITIME-1) |
Amgen | Phase 3 |
Completed |
NCT06858839 |
| Obesity |
Long-term extension study of maridebart cafraglutide for participants who completed MARITIME-1 (MARITIME-1-EXTENSION) |
Amgen | Phase 3 |
Active Not Recruiting |
NCT07684235 |
| Heart failure |
Heart failure with preserved or mildly reduced ejection fraction and obesity |
Amgen | Phase 3 |
Recruiting |
NCT07037459 |
| Cholesterol & prevention |
Preventing heart attack and stroke in people with high lipoprotein(a) |
Eli Lilly and Company | Phase 3 |
Not Yet Recruiting |
NCT07157774 |
| Heart failure |
Heart failure with preserved or mildly reduced ejection fraction |
AstraZeneca | Phase 3 |
Recruiting |
NCT07761117 |
| Cholesterol & prevention |
Preventing heart attack and stroke in people with high LDL cholesterol |
AstraZeneca | Phase 3 |
Recruiting |
NCT07000357 |
Investigator-initiated research (10)
Studies designed and led by Curans Heart Centre researchers, including projects currently seeking funding.
| Research area | Study | Status |
|---|---|---|
| Heart rhythm |
Atrial fibrillation study |
In Preparation |
| Body composition |
Body mass index (BMI) and body surface area (BSA) study |
Awaiting Funding |
| Metabolic health |
Incretin modulators and biological age |
Awaiting Funding |
| Women's heart health |
Incretin modulators in post-menopausal women |
Awaiting Funding |
| Metabolic health |
Incretin–Telomere: cardiometabolic health and telomere biology in Northwestern Ontario |
Awaiting Funding |
| Nutrition |
Vine to Body: whole table grapes, telomere integrity and cardiovascular resilience |
Awaiting Funding |
| Imaging |
Molecular imaging of atherosclerotic plaques using an MPO-targeted hyperpolarized xenon-129 MRI biosensor |
Awaiting Funding |
| Youth wellness |
Youth strength, body composition and wellness project |
Awaiting Funding |
| Heart failure |
Northwestern Ontario Integrated Heart Failure Registry |
Awaiting Funding |
| Diabetes prevention |
A predictive model for diabetes development in First Nations individuals |
Awaiting Funding |